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pentobarbital will reduce the level or influence of conjugated estrogens, vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital decreases amounts of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with powerful CYP3A4 inducers; these m